Tutorial in biostatistics-longitudinal data analysis (repeated measures) in clinical trials.

In addition to repeated measures models given by Albert, there are a number of other procedures under the heading of random e!ects models. In the same issue the paper by Omar et al. [1] and to some extent that by Frost et al. [2] deal with some of these procedures in detail. There are also numerous journal articles, for example, Goldstein et al. [3], which generalize the Chi and Reinsel paper which is referenced by Albert, and a paper by Goldstein and Rasbash [4] which deals with the discrete response case and generalizes the Breslow and Clayton paper which is referenced. There is also the MlwiN software package (http://www.ioe.ac.uk/mlwin/) which is used extensively in health and other areas of application.